In colorectal cancer, YEATS4 drove tumor cell proliferation by promoting cell cycle transition and inhibiting apoptosis (89); in pancreatic cancer, YEATS4 enhanced the stemness of tumor cells and mediated resistance to gemcitabine by binding to H2A.Z.2 and activating the Notch1 signaling pathway (90); in non-small cell lung cancer, YEATS4 amplification antagonized cellular senescence by inhibiting the p53-p21 pathway, promoted proliferation, and led to cisplatin resistance (91). The gene discussed is NOTCH1; the disease is familial pancreatic carcinoma.