MMP16 and central nervous system cancer: Based on marker gene expression patterns, we identified 9 distinct glioma cell subtypes (Figure 3A), including C0 CHI3L1+ glioma cells, C1 MMP16+ glioma cells, C2 PCLAF+ glioma cells, C3 BIRC5+ glioma cells, C4 NDRG1+ glioma cells, C5 TYROBP+ glioma cells, C6 STMN2+ glioma cells, C7 CXCR4+ glioma cells, and C8 MX1+ glioma cells.