Representing the predominant etiology of dementia worldwide, AD constitutes approximately 60-80% of diagnosed cases (1, 2) Central to its pathogenesis are two pathological signatures: extracellular aggregates of amyloid-beta (Aβ) peptides and intraneuronal tau-based neurofibrillary pathology arising from aberrant tau phosphorylation. This evidence concerns the gene MAPT and Alzheimer disease.