Our study identified a novel PCDS comprising nine genes (CFLAR, FYCO1, HDAC1, ITGB1, NFKB1, S100A4, SPAG9, TMEM150A, WDR6) that robustly predicts and classifies Alzheimer’s disease (AD). This evidence concerns the gene HDAC1 and early-onset autosomal dominant Alzheimer disease.