reported that in human colon cancer Caco-2BBe cells, HDAC8 is essential for NF-κB activation, which downregulates solute carrier family 26 member 3 (Slc26a3) and tight junction (TJ) proteins like ZO-1, occludin-1, and claudin-1. The gene discussed is SLC26A3; the disease is colonic neoplasm.