KEGG pathway analysis further indicated that Creb3-regulated target genes are primarily associated with endoplasmic reticulum protein processing and viral infection pathways (Supplementary Figure S3E), emphasizing Creb3’s critical role in regulating cellular ER stress and UPR, whose mediated transcriptional regulatory network disruption might be a key pathogenic mechanism allowing Chlamydia to invade GC cells. The gene discussed is CREB3; the disease is viral infectious disease.