Moreover, we also discovered a significant positive correlation between Creb3 and Ido1 expression in GC cells (Supplementary Figure S3F), which is thought to possibly constrain the specific expression of Ido1 in GC cells by inhibiting Creb3 activity post-Chlamydia infection, leading to impaired GC cell barrier function. Here, IDO1 is linked to chlamydia infectious disease.