CREB3 and chlamydia infectious disease: Additionally, based on the regulatory strength scores of target genes regulated by each TF, we found that Creb3 might strongly regulate the expression of numerous antimicrobial genes in GC cells, such as Ly6a, Lypd8l, Tap1, Ligp1, Lgals9, and specifically the downregulated Ido1 (Figure 4D), further showcasing Creb3’s importance in combating Chlamydia infection and host defense.