Correlation analysis further confirmed a strong positive relationship between P4hb expression and Creb3 (Supplementary Figure S4D), suggesting that P4hb might activate Creb3-mediated transcriptional regulatory networks associated with anti-infection, therefore, the Lgals9-P4hb signaling pathway in intestinal GC might have substantial potential against Chlamydia infection and immune evasion (Figure 5C). Here, CREB3 is linked to chlamydia infectious disease.