In a multivariate analysis, which included ARHGAP25, RhoA, lymph node metastasis (LNM), and TNM stage as covariates, the presence of VM increased the risk of death (multivariate HR 1.872, 95% CI: 1.195-2.933, p=0.006). The gene discussed is RHOA; the disease is metastatic malignant neoplasm in the lymph nodes.