FBL and neoplasm: For instance, in tumors such as ovarian cancer and hepatocellular carcinoma, thrombin time (TT) has been implicated in the microvascular invasion and metastasis of tumor cells (8, 9), while fibrinogen (Fib) can enhance the metastatic potential of tumor cells by inhibiting natural killer (NK) cell-mediated clearance of tumor cells within blood vessels (10).