NFKB1 and osteosarcoma: Research have shown that there is a complex interactive regulatory relationship between the NF-κB signaling pathway and the Wnt/β-catenin signaling pathway in the development of osteosarcoma, and the two pathways interact to jointly affect the biological behavior of osteosarcoma cells, especially in the characteristics of tumor stem cells, tumor cell proliferation and metastasis (146).