It is worth noting that Liao and his team (101) found through cell-level research that compared with normal bone cells, the expression level of the NF-κB signaling pathway in the OS cell line U20S was significantly increased, and its abnormally high expression state was positively correlated with the enhancement of the malignant phenotype of tumor cells (including invasion and metastasis ability). This evidence concerns the gene NFKB1 and neoplasm.