The structural activation of NF-κB is a novel marker of OS, and it has been demonstrated in vitro and in animal models that this pathway is involved in the regulation of tumor cell proliferation, apoptosis, epithelial-mesenchymal transformation, tumor angiogenesis, invasion and metastasis, tumor angiogenesis, and tumor cell drug resistance through complex molecular mechanisms. Here, NFKB1 is linked to neoplasm.