It is reported that the abnormal activation of the NF-κB signaling pathway can promote tumor angiogenesis through a dual regulatory mechanism of up-regulating the expression of vascular endothelial growth factor (VEGF) gene to enhance pro-vascular signaling and accelerating extracellular matrix remodeling by activating members of the MMPs family (106, 107). The gene discussed is VEGFA; the disease is neoplasm.