From the perspective of tumor biology, the carcinogenic effect of NF-κB presents multi-target characteristics: 1) It drives tumor angiogenesis by inducing the secretion of pro-angiogenic factors such as VEGF and IL-8; 2) Activate transcription factors to promote epithelial-mesenchymal transition (EMT); 3) Up-regulating drug drainage pumps (such as MDR1) and DNA repair enzymes enhances chemotherapy tolerance (12). The gene discussed is VEGFA; the disease is neoplasm.