ACEI - angiotensin-converting enzyme inhibitor; AF - atrial fibrillation; ARNI - angiotensin receptor/neprilysin inhibitor; BMI - body mass index; CKD - chronic kidney disease; DBP - diastolic blood pressure; DM - diabetes mellitus; LVEF - left ventricular ejection fraction; LVEDD - left ventricular end diastolic diameter; NS - non-significant; NT-proBNP - N-terminal pro-B-type natriuretic peptide; NYHA - New York Heart Association; SBP - systolic blood pressure; % Cens. The gene discussed is MME; the disease is diabetes mellitus.