Major predictors include high serum ammonia levels, high MELD or MELD-Na values, indications of renal impairment with high creatinine, hyponatremia, systemic inflammatory markers, including C-reactive protein (CRP)q or white blood cell count, and Acute-On-Chronic Liver Failure (ACLF) scores [9]. Here, CRP is linked to acute-on-chronic liver failure.