CKD: chronic kidney disease; CV: cardiovascular; FIDELIO-DKD: Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease; EPHESUS: Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study; RALES: Randomized Aldactone Evaluation Study; MRA: mineralocorticoid receptor antagonist; FIGARO-DKD: Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease; MI: myocardial infarction; HF: heart failure. The gene discussed is NR3C2; the disease is diabetic kidney disease.