T2D: type 2 diabetes, CV: cardiovascular, MI: myocardial infarction, MACE: major adverse cardiovascular events, HFpEF: heart failure with preserved ejection fraction, EF: ejection fraction, BMI: body mass index, KCCQ-CSS: Kansas City Cardiomyopathy Questionnaire Clinical Summary Score, CRP: C-reactive protein, GLP-1 RA: glucagon-like peptide-1 receptor agonist, SGLT2: sodium-glucose cotransporter 2, GIP: glucose-dependent insulinotropic polypeptide, GI: gastrointestinal. This evidence concerns the gene GCG and heart failure.