SGLT2 inhibitors, such as dapagliflozin and empagliflozin, have recently shown promise in reducing heart failure events across a spectrum of ejection fractions (EMPEROR-Preserved, DELIVER), yet their impact on symptom burden, exercise capacity, and quality of life in obesity- or T2D-related HFpEF remains limited [11,12]. Here, SLC5A2 is linked to heart failure.