CRP ≥110.5 mg/L (B=2.35; 95% CI: 1.42-3.21; p<0.001), choledocholithiasis (B=15.31; 95% CI: 4.34-19.12; p=0.010), and MS (B=11.46; 95% CI: 5.00-21.49; p=0.017) were identified as significant predictors of prolonged LOS. Here, CRP is linked to choledocholithiasis.