The search strategy incorporated controlled vocabulary (e.g., MeSH terms) and keywords such as “renin-angiotensin-aldosterone system,” “cognition,” “dementia,” “angiotensin receptor blockers,” “ACE inhibitors,” and “neuropsychiatric outcomes.” Boolean operators were employed to refine results, and filters were applied to restrict studies to those published in English and involving human or relevant animal models. The gene discussed is REN; the disease is dementia.