This review provides an overview of how to study the general aspects of AD ex vivo, focusing on (a) β-amyloid plaques in brain slices, (b) tau pathology induced by chemical drugs, (c) cell death of cholinergic neurons and protection by nerve growth factor, (d) activation of astrocytes and microglia, and (e) vascular pathologies, including the role of platelets. The gene discussed is MAPT; the disease is Alzheimer disease.