Recent studies have revealed the key role of KLB in regulating lipid metabolism and bile acid (BA) metabolism (Somm et al., 2018), KLB knockout mice exhibit altered BA composition, hepatic inflammation, and early fibrosis, indicating that KLB deficiency disrupts the liver-gut BA circuit and induces lipid metabolism disorders (Somm et al., 2018). Here, KLB is linked to Disorder of lipid metabolism.