The results revealed that CGAS was highly detected in CCA, PAAD, ESCA, and STAD when compared to the normal counterparts, while STING, TBK1, IRF3, RELA, and NFKB1 were significantly upregulated in CCA and PAAD (p < 0.05). The gene discussed is RELA; the disease is pancreatic adenocarcinoma.