↑Accumulation in fibrotic liver tissue ↓ ROS ↓Transforming growth factor-beta (TGF-β) production targeted lysosomal degradation of TGF-βInhibition of TGF-β-Smad2/3 signaling pathway↓ECM secretion Significant attenuation of liver fibrosis. Here, SMAD2 is linked to Hepatic fibrosis.