In addition, inflammatory mediators, including TGF-β1, TNF-α, EGF, and IGF, are also released by injured hepatocytes and activated hepatic stellate cells, ultimately activating T cells [4], which are pivotal to both TH2-mediated fibrosis and TH17-mediated inflammation in liver fibrosis. The gene discussed is TGFB1; the disease is Hepatic fibrosis.