TGFB1 and Hepatic fibrosis: ↑Accumulation in fibrotic liver tissue ↓ ROS ↓Transforming growth factor-beta (TGF-β) production targeted lysosomal degradation of TGF-βInhibition of TGF-β-Smad2/3 signaling pathway↓ECM secretion Significant attenuation of liver fibrosis