CXCR3 and one or more of its ligands have been found to be overexpressed in a variety of inflammatory diseases, including allograft rejection, atherosclerosis, autoimmune diseases, Examples include rheumatoid arthritis (RA), inflammatory bowel disease (IBD), chronic obstructive pulmonary disease (COPD), multiple sclerosis (MS), and systemic lupus erythematosus (SLE) (Figure 3). The gene discussed is CXCR3; the disease is autoimmune disease.