The ratio of CXCR3-A to CXCR3-B is higher in renal cell carcinoma (RCC) tissues compared to normal kidney tissues, and the total expression of CXCR3 and CXCR3-A is significantly higher in metastatic RCC tissues than in non-metastatic RCC tissues (Gudowska-Sawczuk et al., 2020). The gene discussed is CXCR3; the disease is hereditary clear cell renal cell carcinoma.