The involvement of ACKR2 in CXCL14-triggered signaling pathways, such as phospholipase Cβ3, protein kinase Cα, and proto-oncogene tyrosine-protein kinase Src, which subsequently upregulate nuclear factor kappa B transcriptional activity, leads to cancer cell EMT and migration (Chang et al., 2023). The gene discussed is CXCL14; the disease is cancer.