Further research found that GA can reverse the decline of peroxisome proliferator-activated receptor alpha (PPAR-α) and liver X receptor-alpha (LXR-α) and the increase of sterol regulatory element-binding protein-1c (SREBP-1c) mRNA caused by HFD by anti-oxidative stress and improving steatopathy, thus alleviating NAFLD (Chen et al., 2011). Here, SREBF1 is linked to metabolic dysfunction-associated steatotic liver disease.