Its mechanisms include inhibition of the phosphorylation of MST1/2 and LATS1/2 within the Hippo pathway, thereby reversing YAP/TAZ suppression, alleviating NPC senescence, and mitigating IDD progression by regulating ECM metabolism and preserving tissue structural integrity (Zhou et al., 2022). The gene discussed is YAP1; the disease is intervertebral disk degenerative disorder.