NLRP3 and intervertebral disk degenerative disorder: Additionally, naringin protected endplate chondrocytes from apoptosis by promoting SIRT3-mediated mitophagy and suppressing NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation (Wang J. et al., 2024), which is involved in the IDD pathological process (Chao-Yang et al., 2021).