In IL-1β-induced in vitro IDD models, kaempferol inhibited phosphorylation of ERK1/2, downregulated matrix metalloproteinase (MMP)-3 and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4, while upregulating aggrecan and type II collagen expression. Here, ACAN is linked to intervertebral disk degenerative disorder.