The concurrent reductions in serum triiodothyronine (T3), thyroxine (T4), thyrotropin-releasing hormone (TRH), free fatty acids (FFA), lipoprotein lipase (LPL), and nitric oxide (NO) levels are consistent with the hallmark metabolic depression and energy deficit characteristic of Kidney Yang Deficiency (KYD). This evidence concerns the gene TRH and depressive symptom measurement.