In vitro experiments further confirmed that palmatine (5.5–7.9 μM) concentration-dependently induced apoptosis in OVCAR-4 cancer cells through enhanced caspase-3/7 activity and poly (ADP-ribose) polymerase cleavage, consequently inhibiting ovarian cancer cell growth (Johnson-Ajinwo et al., 2019). This evidence concerns the gene CASP3 and cancer.