FOS and epilepsy: Instead, it exerts antiepileptic activity by significantly downregulating the epilepsy-associated immediate-early gene FBJ murine osteosarcoma viral oncogene homolog (c-Fos) expression and reducing neurotrophic factor BDNF levels - a gold-standard biomarker reflecting abnormal neuronal discharges and synaptic remodeling (Gawel et al., 2020).