Palmatine induced apoptosis by suppressing survivin and glioma-associated oncogene homolog (GLI) signaling pathways, as well as the activation of collagen type I alpha 1 (COL1A1), thereby disrupting glutamine-mediated crosstalk between pancreatic cancer cells (PCCs) and PSCs. The gene discussed is COL1A1; the disease is pancreatic neoplasm.