Regarding immune cell composition, the metaplasia group exhibited the similar TME as in CRC samples with the enrichment of specific CD4+ T cell subtypes such as CD4_Th17_IL17A (C30) and CD4_Tcm_CD40LG (C31) and B cell subtypes like Naive B_IGHD (C0) and memory B_TNFRSF13B (C1) (Figure 7G,H). This evidence concerns the gene CD4 and colorectal carcinoma.