Analysis of the TCR‐α and TCR‐β chain (TRA/TRB) repertoires, focusing on expression levels of TRAV/TRAJ and TRBV/TRBJ region genes, identified skewed T‐cell clones (i.e., T cells with the same antigen specificity become abnormally dominant) in two TFR cases (i.e., CML‐7 and CML‐53); however, case CML‐43 did not exhibit such skewing. This evidence concerns the gene TFRC and chronic myelogenous leukemia, BCR-ABL1 positive.