MAPT and Alzheimer disease: Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder characterized by a decline in memory and other cognitive functions, significantly impacting patients’ social lives.[1] AD represents the most prevalent cause of dementia, particularly among the elderly, accounting for approximately 60% to 70% of cases.[2] The etiology of AD is complex and multifactorial, involving cholinergic deficiency, the accumulation of amyloid plaques, and neurofibrillary tangles composed of aggregated tau protein within the brain.[3]