Here we focus on CFTR expression in cell types that are less well‐characterised for gene regulatory mechanisms and yet pivotal in CF pathology, including pancreatic duct cell lines, primary human pancreatic duct cell organoids [19], bile duct epithelial cell (cholangiocyte) organoids [20] and sweat gland duct and coil cells [21]. The gene discussed is CFTR; the disease is cystic fibrosis.