In reverse MR analyses, 12, 20, 9, 484, 130, 135, 60, 7 and 338 SNPs linked to ARF, CKD, RD, eGFR, BUN, UACR, MAU, KIM-1 and CysC were screened from the mtDNA CN GWAS database (Supplementary Table S5). Here, HAVCR1 is linked to acute kidney injury.