In addition, FoxO3 overexpression protected against DOX‐induced cardiomyopathy by activating the autophagy in vivo, which was demonstrated by increased expression of LC3 II/I ratio, Beclin 1 and decreased p62 and p‐mTOR/mTOR ratio, as well as reducing the expression of apoptotic protein Bax/Bcl2 ratio (Figure 7O,P). The gene discussed is FOXO3; the disease is cardiomyopathy.