After treatment with L‐tianma, M‐tianma, or H‐tianma granules, or 5‐Fu, compared to the CRC group, these trends were reversed: AXIN1 levels were significantly increased, while p‐GSK‐3β, β‐catenin, Wnt5a, CyclinD1 and c‐Myc levels were significantly decreased (Figure 6A). This evidence concerns the gene AXIN1 and colorectal carcinoma.