Tianma granules also downregulated the level of CRC‐specific markers (COX2 and MUC2), inhibited the inflammation (decreased TNF‐α, IL‐1β, IL‐6 levels and increased INF‐γ level), and promoted apoptosis (decreased TUNEL positive cell rate; decreased Bax and Cleaved caspase3 protein levels and increased Bcl2 level) in CRC mice. The gene discussed is IL1B; the disease is colorectal carcinoma.