FCGR2A and neoplasm: Macrophages recognize and internalize various complex targets via a wide range of phagocytic receptors.145 In tumor-specific antibody immunotherapy, stable conjugates form between tumor cells and macrophages expressing Fcγ receptors (FcγRs).146 Among these conjugates, actin, FcγR, and tyrosine phosphoproteins accumulate in multifocal SMACs.