CD8A and neoplasm: This leads to a reduction in brain inflammation and impairment of antitumor immunity by inhibiting the cytotoxicity of NK cells and CD8+ T cells.355 γδ T cells are also victimized by the accumulation of metabolic waste in the TME, as excessive lactic acid significantly reduces the transport of cytotoxic granules to the Vγ9Vδ2 T cell-tumor synapse by inhibiting AMPK activation, resulting in the loss of antitumor activity in vitro, in vivo, and in patients.356