CD274 and neoplasm: Furthermore, in-depth exploration of PD-1/PD-L1 has revealed that part of the inhibition of T cell activity by PD-1 is due to its spatial position within the IS, which suppresses actin remodeling at the synapse and thus hinders the contact with APCs and the release of cytotoxic granules.471 Therefore, modifications to traditional PD-1 antibodies can maximize T cell activation and tumor-killing effects by altering the position of PD-1 within the IS and simultaneously inhibiting PD-1/PD-L1 binding.29,472