Under inflammatory conditions, galectin-4-mediated CD4+ T cell activation exacerbates chronic colitis and delays recovery from acute intestinal injury.54 Further studies demonstrated that galectin-4 requires interaction with a specific binding glycome to stabilize active PKCθ, inhibit synapse disassembly, and drive persistent memory CD4+ T cell expansion in colitis.436. This evidence concerns the gene LGALS4 and colitis.