While NgR1 has been reported to regulate actin cytoskeleton dynamics in neuronal synapses by activating the RhoA pathway, its role in tumor immunity has only recently been explored.143 NgR1 inhibits IS formation by modulating actin dynamics via the LIMK-cofilin pathway, which suppresses F-actin accumulation and granule polarization, thus reducing NK cell cytotoxicity. Here, RTN4R is linked to neoplasm.