AKT1 and breast cancer: Exosomes containing miR-196a, secreted by CAFs, confer cisplatin resistance in advanced head and neck cancers by targeting CDKN1B, whereas neuregulin 1 (NRG1)-expressing CAFs contribute to trastuzumab resistance in HER2-positive breast cancer through activation of the HER3/AKT pathway; these exosomes primarily originate from myCAFs [56].