H4K5la promoted PD-L1 expression and drive immunosuppression in acute myeloid leukemia (31), whereas H4K12la activated the transcription of HIF1A, PKM, and LDHA, thereby promoting glycolysis and forming a positive feedback glycolysis/H4K12la/PKM2 loop in microglia (32). This evidence concerns the gene CD274 and acute myeloid leukemia.