In NEC stage II, strong correlations were observed between CRP and serum calprotectin (r = 0.765, p < 0.05), CRP and fecal calprotectin (r = 0.868, p < 0.05), and between serum and fecal calprotectin (r = 0.852, p < 0.05). This evidence concerns the gene CRP and necrotizing enterocolitis.