When comparing CRP, IL-6, serum calprotectin, and fecal calprotectin concentration between patients who underwent surgery and those who did not, as well as between NEC survivors and non-survivors, it was found that IL-6, serum calprotectin, and fecal calprotectin concentration were elevated in both infants requiring surgical intervention and those who did not survive (Table 3). The gene discussed is IL6; the disease is necrotizing enterocolitis.