Fecal biomarkers, such as calprotectin12 human S100A1216 intestinal fatty acid-binding proteins (I-FABP)17 and intestinal alkaline phosphatase activity18 along with urinary biomarkers including I-FABP17 and serum amyloid A (SAA)19 and serum biomarkers such as cytosolic β-glucosidase20 SAA,21 inter-alpha inhibitor proteins22 various differentially expressed genes23 and absolute monocyte count, have all been investigated for their potential in the prediction and early detection of NEC. This evidence concerns the gene FABP2 and necrotizing enterocolitis.