This is probably because MZB-1 stains B1/MZB/plasma cells, and plasma cells are strongly associated with the Th2 (humoral) response in leprosy, which is scarce in the Th1 pole.25, 26 In addition, the authors observed that, in double-labeling techniques, MZB and B1-cells were much scarcer than CD20-positive cells in all groups of patients, including TT. This evidence concerns the gene MZB1 and leprosy.