Be1 and Be2 cells, in turn, play roles in promoting the in vitro differentiation of Th1 and Th2 cells, respectively.16, 31 Subsequently, it was revealed that B-cell-derived IFN-γ plays a crucial role in Th1 responses, contributing to allograft and tumor rejection, autoimmune arthritis, and antibacterial response.32, 33, 34. This evidence concerns the gene IFNG and neoplasm.