KEGG pathway enrichment analysis indicated that IQ's mechanism for preventing and treating II/R involved 145 pathways, including proteoglycans in cancer, pathways in cancer, VEGF signaling pathway, AGE-RAGE signaling pathway in diabetic complications, lipid and atherosclerosis, inflammatory mediator regulation of TRP channels, chemokine signaling pathway, leukocyte transendothelial migration, and platelet activation (Fig. 5F). This evidence concerns the gene VEGFA and atherosclerosis.