VEGFA and cancer: KEGG pathway enrichment analysis indicated that IQ's mechanism for preventing and treating II/R involved 145 pathways, including proteoglycans in cancer, pathways in cancer, VEGF signaling pathway, AGE-RAGE signaling pathway in diabetic complications, lipid and atherosclerosis, inflammatory mediator regulation of TRP channels, chemokine signaling pathway, leukocyte transendothelial migration, and platelet activation (Fig. 5F).