Multivariate logistic regression analysis identified age (OR = 1.12, 95% CI: 1.04–1.20, p = 0.003), history of stroke (OR = 10.94, 95% CI: 1.32–90.66, p = 0.027), EuroSCORE II (OR = 2.90, 95% CI: 1.61–5.20, p < 0.001), NT-proBNP level (OR = 1.002, 95% CI: 1.001–1.004, p = 0.009), hs-CRP level (OR = 1.55, 95% CI: 1.16–2.07, p = 0.003), and operation time (OR = 1.02, 95% CI: 1.01–1.04, p = 0.008) as independent predictors of POAF. This evidence concerns the gene NPPB and stroke disorder.