After adjusted the age, sex, education level, race, SBP, DBP, BMI, AST, ALT, Urine iodine, DM and Hyperlipidemia (Model 3), FT4 was positively correlated with the prevalence of CKD (OR = 1.08; 95% CI = 1.05–1.12, P < 0.0001).FT3/FT4 and TFQIFT3 were negatively correlated with mortality in patients with CKD (OR = 0.13; 95% CI = 0.05–0.32, P < 0.0001; OR = 0.76; 95% CI = 0.58–1.00, P = 0.05). This evidence concerns the gene GPT and hyperlipidemia.