In contrast, activation of the PI3K/AKT pathway has been observed in PDAC, oral and salivary gland tumours, prostate cancer (PC) and glioma (Chen et al. 2021; Jiang et al. 2020a, b; Meco et al. 2019; Alkhadar et al. 2020). This evidence concerns the gene AKT1 and glioma.