Moreover, the aggression of PC cells might be aroused by NGF derived from perifocal cells, e.g., coculture with cancer-associated fibroblasts (CAFs) upregulates Yes-associated protein 1 (YAP1) in PC cells, which recruits TEA domain family member 1 (TEAD1) to the NGF promoter, sustaining NGF secretion and the perineural invasion of PC cells (Shen et al. 2022). Here, NGF is linked to pachyonychia congenita.