As PC develops and progresses, even though PC expresses both receptors, TrkA and NGF are upregulated, whereas p75NTR expression is gradually diminished, along with increased cell viability and invasion (Anagnostopoulou et al. 2013; Donato et al. 2019; Baspinar et al. 2017). The gene discussed is NTRK1; the disease is pachyonychia congenita.