Regarding the current first-line SOC for ES-SCLC, the Chemo + PD-1 regimen had the highest probability of ranking first for anemia (SUCRA = 0.91) and vomiting (SUCRA = 0.95), while the Chemo + PD-L1 regimen had the highest probability for leukopenia (SUCRA = 0.93). This evidence concerns the gene CD274 and small cell lung carcinoma.