The follow-up of extrathoracic primary tumor patients one year after metastasectomy is shown in Supplementary Table 2B. Immunophenotyping of the peripheral blood lymphocytes by multiparameter flow cytometry revealed significantly lower lymphocyte counts (Fig. 5A) in all tumor stages and significantly decreased ratios of CD3-/CD19 + B cells in advanced tumor stages (Fig. 5B). This evidence concerns the gene CD19 and neoplasm.