A previous single-centre study shows significantly lower levels of IL-6, IL-8, and tumor necrosis factor (TNF) in patients with COVID-19-associated ARDS (n = 62) compared to septic shock patients with (n = 51) and without (n = 15) ARDS and a mixed picture when comparing COVID-19 to trauma (n = 62) and out-of-hospital cardiac arrest (n = 30)15. This evidence concerns the gene TNF and COVID-19.