To determine whether the Eps8l2-G3bp2 axis contributes to tumor development in this AOM/DSS model, we examined G3bp2 and Ki67 expression by IHC staining and found a significant decrease of G3bp2 and Ki67 expression levels in tumor tissues from Eps8l2−/− mice (Fig. 8I). This evidence concerns the gene MKI67 and infectious otitis media.