Specific targets, such as NFKBIA, Cxcl12 (C‐X‐C motif chemokine ligand 12) and Vav3, along with key signalling pathways like chemokine, Wnt and NF‐kappa B, may mediate the effects of exercise on METH‐induced learning and memory impairments. This evidence concerns the gene CXCL12 and memory impairment.