While NET G3 generally retains the organoid pattern and wild‐type TP53 and Rb1 gene profiles of well‐differentiated neuroendocrine neoplasms (NENs), NEC usually shows a disorganised pattern, significant cellular atypia, and genetic abnormalities that resemble their exocrine counterparts, including TP53, KRAS, BRAF, or Rb1 genes, among others.2, 3. This evidence concerns the gene TP53 and neuroendocrine neoplasm.