RB1 and neuroendocrine neoplasm: While NET G3 generally retains the organoid pattern and wild‐type TP53 and Rb1 gene profiles of well‐differentiated neuroendocrine neoplasms (NENs), NEC usually shows a disorganised pattern, significant cellular atypia, and genetic abnormalities that resemble their exocrine counterparts, including TP53, KRAS, BRAF, or Rb1 genes, among others.2, 3