Apigenin decreased hypoxia‐induced activation of HIF‐1α and Akt pathways in metastatic prostate cancer cells (Mirzoeva et al. 2008), by decreasing both the stability of HIF‐1α protein and down‐regulating steady state HIF‐1α mRNA in normoxic and hypoxic conditions (Mirzoeva et al. 2008). This evidence concerns the gene HIF1A and Familial prostate cancer.