Apigenin decreased hypoxia‐induced activation of HIF‐1α and Akt pathways in metastatic prostate cancer cells (Mirzoeva et al. 2008), by decreasing both the stability of HIF‐1α protein and down‐regulating steady state HIF‐1α mRNA in normoxic and hypoxic conditions (Mirzoeva et al. 2008). The gene discussed is AKT1; the disease is Familial prostate cancer.