These extracellular vesicles, characterized by the presence of the SORT1‐EGFR‐TrkB complex (hereafter referred to as the TES complex), can be internalized by recipient cells, promoting angiogenesis and enhancing cellular proliferation, survival, adhesion, and migration of NSCLC cells [24]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.