In 2010, using small interfering RNA (siRNA)‐mediated candidate gene silencing and whole‐cell patch‐clamp electrophysiology to record the MA cationic current, Piezo1 (also known as Fam38A) was identified as being responsible for mediating endogenous MA currents in neuroblastoma (Neuro2a) cell lines [10, 11]. The gene discussed is PIEZO1; the disease is neuroblastoma.