To this end, we leveraged the highly sensitive NUcleic acid Linked Immuno‐Sandwich Assay (NULISATM),11 to analyze a predefined panel of 120 protein targets in serum and CSF samples of 9 SOD1‐ALS patients treated with tofersen and 9 matched control subjects. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.