Of note, besides NfH and NfL, GOT1, NPY, Aβ1–42 (strong trend also for Aβ1–40), CD40LG, and UCHL1 were inversely altered in untreated SOD1‐ALS versus controls, indicating that these markers could be useful for both diagnostic and therapeutic purposes (Fig. S10). Here, NEFL is linked to amyotrophic lateral sclerosis.