34 patients with PSVD (17 PH+ and 17 PH−) and 17 healthy subjects were submitted to measurement of zonulin and lipopolysaccharides (LPS), markers of intestinal permeability, of s‐Glycoprotein VI, sP‐selectin, ADAMTS13 and von Willebrand factor (vWF), markers of platelet aggregation and vascular dysfunction, factor VIII and F1 + 2, markers of hypercoagulability. This evidence concerns the gene HP and thrombophilia.